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Ayala Pharmaceuticals, Inc. (AYLA)

Sector - Healthcare

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IPO Profile

About company

They are a clinical-stage oncology company focused on developing and commercializing small molecule therapeutics for patients suffering from rare and aggressive cancers, primarily in genetically defined patient populations. Their differentiated development approach is predicated on identifying and addressing tumorigenic drivers of cancer, through a combination of their bioinformatics platform and next-generation sequencing to deliver targeted therapies to underserved patient populations. Their current portfolio of product candidates, AL101 and AL102, targets the aberrant activation of the Notch pathway with gamma secretase inhibitors. Gamma secretase is the enzyme responsible for Notch activation and, when inhibited, turns off the Notch pathway activation. Aberrant activation of the Notch pathway has long been implicated in multiple solid tumor and hematological cancers and has often been associated with more aggressive cancers. In cancers, Notch is known to serve as a critical facilitator in processes such as cellular proliferation, survival, migration, invasion, drug resistance and metastatic spread, all of which contribute to a poorer patient prognosis. AL101 and AL102 are designed to address the underlying key drivers of tumor growth, and their initial Phase 2 clinical data of AL101 suggest that their approach may address the shortcomings of existing treatment options. They believe that their novel product candidates, if approved, have the potential to transform treatment outcomes for patients suffering from rare and aggressive cancers.
Roni Mamluk Yossi Maimon
Employees Founded
29 2017


Address: Oppenheimer 4, Rehovot 7670104, Israel

Telephone: +972-8-373-1541

Web page:

IPO information

Expected Date 5/8/2020
Status Priced
Exchange NASDAQ
Lockup Period Expiration .Pro
Quiet Period Expiration .Pro
Old Price Range
Share prices ($)

Financial Data (last reporting year)

Market Cap (MM) $181.7
Revenues (MM) $2.3
Net Income (Loss) (MM) $-17.8


What do you think will happen with the AYLA share price after the next 3-6 months? 🔥 (+ 10% or more, flat (+ -10%), -10% or less)

Number of votes: img
Shares Initial (MM) 3.3
Shares Revised (MM) 3.7
Expected offer amount (MM) $55
Realized offer amount(MM) $55.5
Citigroup/ Jefferies
Oppenheimer/ Raymond James

Sector: Healthcare

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