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More companies

Pharvaris B.v. (PHVS)

Sector - Healthcare

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IPO Profile

About company

They are a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapies for rare diseases with significant unmet need, initially focused on angioedema and other bradykinin-mediated diseases. Their first molecule, PHA121, is a novel, small molecule bradykinin B2-receptor antagonist for the treatment of hereditary angioedema, or HAE. Bradykinin-B2-receptor inhibition is a clinically validated mechanism for the treatment of HAE, as demonstrated by icatibant, which is a bradykinin B2-receptor antagonist approved in Europe in 2008 and in the United States in 2011 (as FIRAZYR). They designed PHA121 to improve upon the therapeutic profile of existing therapies and, through oral delivery, to provide patients with quality of life and convenience that is superior to current standard-of-care HAE treatments, which are injectables. They believe PHA121 has the potential to provide a safe, effective and convenient option for both acute and prophylactic treatments of HAE, in the form of their PHVS416 on-demand rapid exposure product candidate, and for prophylaxis of HAE, in the form of their PHVS719 small daily dose extended-release product candidate. They believe that their product candidates may address a broader range of angioedema attacks than other available treatments since PHA121 blocks the actual signal that leads to angioedema (the interaction of bradykinin, or BK, with the bradykinin B2 receptor), rather than an upstream signal.
Berndt Modig Morgan Conn
Employees Founded
14 2015


Address: J.H. Oortweg 21, 2333 CH Leiden, The Netherlands

Telephone: +31 (0)71 203 6410

Web page:

IPO information

Expected Date 2/5/2021
Status Priced
Exchange NASDAQ
Lockup Period Expiration .Pro
Quiet Period Expiration .Pro
Old Price Range
Share prices ($)

Shares & Volumes

Shares Initial (MM) 6.95
Shares Revised (MM) 8.3
Expected offer amount (MM) $125.1
Realized offer amount(MM) $166

Financial Data (last reporting year)

Market Cap (MM) $549.36
Revenues (MM) $0
Net Income (Loss) (MM) $-9.75


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The lead left underwriter: Morgan Stanley

IPOs led by the firm .Pro
Profitability of conducted IPOs  ?  .Pro
1st day change  ?  .Pro
Change for the first 3 months  ?  .Pro
Morgan Stanley/ BofA Securities/ SVB Leerink
Oppenheimer/ Kempen & Co.

Sector: Healthcare

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