Vigil Neuroscience, Inc. (VIGL)

They are a microglia-focused company dedicated to improving the lives of patients, caregivers and families affected by rare and common neurodegenerative diseases by pursuing the development of disease-modifying therapeutics to restore the vigilance of microglia. Microglia are the sentinel immune cells of the brain and play a critical role in maintaining central nervous system (CNS) health and responding to damage caused by disease. Leveraging recent research implicating microglial dysfunction in neurodegenerative diseases, they utilize a precision medicine approach to develop a pipeline of therapeutic candidates, initially addressing genetically defined patient subpopulations, that they believe will activate and restore microglial function. Their lead candidate, VGL101, is a fully human monoclonal antibody (mAb) that is initially being developed for adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). In November 2021, the FDA cleared their Investigational New Drug application (IND) for VGL101 in ALSP at doses up to 20 mg/kg. They initiated their first-in-human Phase 1 clinical trial with VGL101 in healthy volunteers in December 2021 and expect to announce topline data in the second half of 2022.

Industry
Pharmaceutical Preparations

CEO	CFO
-

Employees	Founded
34	2020

Address: 1 Broadway, 7th Floor, Suite 07-300 Cambridge, Ma 02142

Telephone: (857) 254-4445

Web page: http://www.vigilneuro.com

First Trade Date	1/7/2022
Status	Priced
Exchange	NASDAQ
Lockup Period Expiration	.Pro
Quiet Period Expiration	.Pro
Old Price Range	-

Share prices ($)

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The lead left underwriter: Morgan Stanley

Over the last 12 months Since the beginning of the year

IPOs led by the firm	.Pro
Profitability of conducted IPOs  ?	.Pro
1st day change  ?	.Pro
Change for the first 3 months  ?	.Pro

IPOs led by the firm	.Pro
Profitability of conducted IPOs  ?	.Pro
1st day change  ?	.Pro
Change for the first 3 months  ?	.Pro

Underwriters
Morgan Stanley/ Jefferies/ Stifel/ Guggenheim Securities
CO-Managers